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A pharmaceutical that ____ is called a controlled drug.

  1. Is labeled with a red warning label.

  2. Requires a prescription.

  3. Has a therapeutic index below 5.

  4. Has addictive properties.

The correct answer is: Has addictive properties.

A pharmaceutical labeled with a red warning label is indicated as having potentially harmful effects and is not necessarily a controlled drug. A pharmaceutical that does not require a prescription can still be considered a controlled drug if it meets other criteria. A therapeutic index below 5 does not automatically classify a pharmaceutical as a controlled drug. A pharmaceutical can have addictive properties without being classified as a controlled drug. Therefore, the best indicator that a pharmaceutical is a controlled drug is whether or not it has addictive properties.